https://www.selleckchem.com/products/vtx-27.html In addition, native clams were vastly affected by OA and DTX1, presenting an increment in the DNA damage since the first day, with a correspondent increase in the repair activity. On the other hand, invasive clams were not affected by the dinoflagellate toxins, exhibiting only some signs of the challenge, namely an increase in the DNA repair mechanisms in the post-exposure period. Invasive clams R. philippinarum are better adapted to cope with harmful algal blooms and OA-group toxins than native species. These results may increase farming interest and may lead to new introductions of the invasive clams. In sympatry sites, exposure to OA-group toxins may unbalance clams species biomass and distribution as exposure to toxic dinoflagellates affects the native clams from cellular to a population level, representing a significant threat to development and maintenance of R. decussatus populations.The study proposes a new set pair analysis - variable fuzzy improved model (SPA-VFIM) by integrating the set pair analysis (SPA), variable fuzzy sets (VFS) theory, and binary semantic (BS). The SPA-VFIM method gets over the shortcomings of the existing SPA and VFS methods. The use of BS solves the problem of the weighted average principle (WAP) not being conducive to the timeliness of assessment. The existing and newly proposed methods were used to evaluate the groundwater quality in the Jiaokou Irrigation District, China, to show the advantages of the SPA-VFIM method. The results of SPA-VFIM method show that more than 80% of the groundwater, mainly distributed in the central and western parts of the study region, is assessed as level IV and level V, according to the Chinese Groundwater Quality Standards (GB/T 14848-2017). The assessment results are consistent with ground-based measurements of water quality, and NO3-, Na+, SO42-, Total Hardness (TH), and Cl- are the main pollutants. The SPA-VFIM and existing methods were compared.