https://www.selleckchem.com/products/Nicotinamide(Niacinamide).html She is currently asymptomatic and being followed up regularly as an outpatient.Background and study aims  The COVID-19 pandemic has caused a major disruption in the healthcare system. This study determined the impact of the first wave of COVID-19 on the number and outcome of patients hospitalized for upper gastrointestinal bleeding (UGIB) in Hong Kong. Patients and methods  Records of all patients hospitalized for UGIB in Hong Kong public hospitals between October 2018 and June 2020 were retrieved. The number and characteristics of patients hospitalized for UGIB after COVID-19 was compared by autoregressive integrated moving average (ARIMA) model prediction and historical cohort. Results  Since the first local case of COVID-19, there was an initial drop in UGIB hospitalizations (observed 29.8 vs predicted 35.5 per week; P  = 0.05) followed by a rebound (39.8 vs 26.7 per week; P   less then  0.01) with a turning point at week 14 (Petitt's test, P   less then  0.001). There was a negative association between the number of COVID-19 cases and the number of patients hospitalized for UGIB (Pearson correlation -0.53, P   less then  0.001). Patients admitted after the outbreak of COVID-19 had lower hemoglobin (7.5 vs baseline 8.3 g/dL; P   less then  0.01) and a greater need for blood transfusion (64.5 % vs baseline 50.4 %; P   less then  0.01), but similar rates of all-cause mortality (6.9 % vs 7.1 %; P  = 0.82) and rebleeding (6.7 % vs 5.1 %; P  = 0.11). There was also a higher proportion of patients with variceal bleeding (10.5 % vs baseline 5.3 %; P   less then  0 .01). Conclusions  There was a dynamic change in the number of patients hospitalized for UGIB in Hong Kong during the first wave of the COVID-19 outbreak, with more obvious impact during the initial phase only.The Capsule Endoscopy Group of the Chinese Society of Digestive Endoscopy has issued recommendations for capsule endoscopy (CE) practic