https://www.selleckchem.com/products/Estrone.html 7%) as compared to angiography normal control group (16.9 %), though was not statistically significant ( = 0.19). When males and females were segregated in multivariate analysis, Le (a-b-) females had a higher incidence of CAD ( = 0.03) with the odds ratio of 4.97, though an association was not found significant in males ( = 0.71). The association between Lewis phenotypes and CAD was not significant in males and in among the overall study population, but this association was statistically significant in females. Further studies based on a larger sample size may substantiate as well as delineate the possible hypotheses. The association between Lewis phenotypes and CAD was not significant in males and in among the overall study population, but this association was statistically significant in females. Further studies based on a larger sample size may substantiate as well as delineate the possible hypotheses. Alloimmunization is an immune response against foreign antigens which introduced into the body through transfusion, pregnancy, or transplantation. This phenomenon is a big challenge in patients, which require regular transfusions. In the current study, we tried to have a comprehensive review on the status of alloimmunization in Iran. For this purpose, we searched for papers investigating alloimmunization in transfusion-dependent patients and also in patients with no regular transfusions who are candidate for surgery or who need blood. We searched PubMed, Google Scholar, SID, and MAGIRAN databases using the following keywords "blood transfusion," "alloimmunization," "alloantibodies," "irregular antibodies," "red cell antibodies," and "Iran." No limitation for the date of publication and language of the papers was defined. All the identified records were then screened for the relevance and duplication. A total of 22 papers were included in this study. All of the studies were conducted from 1999 to 2016 and providing