https://www.selleckchem.com/products/Dihydromyricetin-Ampeloptin.html treatment at reducing pain interference. Building resilience may further reduce the risk of PMD.The present study deals with ***-specific reproductive phase-dependent variation and *** steroids-induced transcriptional regulation of hepatic lep and lepr in nutritionally valuable spotted snakehead, Channa punctata. The data on seasonality reveals ***-specific variation in pattern of lep transcription where a high level was recorded during resting and postspawning quiescent phases in female while during resting and spawning phases in male. Unlike lep, lepr exhibited similar expression pattern along the reproductive phases in both the sexes. As compared to female, a three-fold higher expression of lep was detected in male during reproductively active phase only. However, no sexual dimorphism was evidenced in lepr either during active or quiescent phase. To explore the implication of *** steroids in regulation of leptin system, we correlated levels of plasma testosterone (T) and 17β-estradiol (E2) with leptin system in males as well as females. Further, criss-cross in vivo and in vitro experiments with dihydrotestosterone (DHT) and E2 were conducted in male and female spotted snakehead. The leptin system was downregulated after DHT administration in both the sexes. However, with E2, a marked decrease was evidenced in male only. The ***-wise variable response of leptin system to *** steroids was validated by in vitro experiments wherein liver fragments from male and female fish were incubated individually with both the *** steroids. In conclusion, *** steroids modulate hepatic leptin system differentially depending on *** and reproductive state of spotted snakehead.The relationship between the reproductive (hypothalamic-pituitary-gonadal; HPG) and adrenal (hypothalamic-pituitary-adrenal; HPA) hormone axes is complex and can vary depending on the species and environmental factors affecting an individual.