https://www.selleckchem.com/products/ptc-028.html Most synthetic building blocks self-assemble into one- or three-dimensional architectures. However, fewer examples have been reported on the aggregation of amphiphiles to form optically-active two-dimensional (2D) structures. Herein, we report the self-assembly of tetraphenylethylene (TPE)-containing hydrophilic dendrons into 2D sheet structures in aqueous methanol solution. TEM and AFM investigations showed that the self-assembly of disubstituted TPE generates helical nanofibers as an intermediate structure which, in turn, laterally associate into a chiral sheet structure with a thickness of 4.6 nm, whereas tetrasubstituted TPE self-assembles into a nonchiral sheet structure with a thickness of 3.8 nm. In great contrast to the nonchiral sheets, the chiral sheets are able to preferentially absorb the d-enantiomer in a racemic phenylalanine derivative solution accompanied by fluorescence enhancement, thus indicating that the single-layered chiral sheets act as an enantioselective membrane that can be used for fluorescence sensing. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.Invited for this month's cover are the groups of George John at the City College of New York-CUNY, Leela R. Arava at Wayne State University, and Pulickel Ajayan at Rice University. The image portraits future prospects of bioderived molecular electrodes for next-generation energy-storage materials. The Minireview itself is available at 10.1002/cssc.201903589. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.A number of hormones and growth factors stimulate target cells via the second messenger pathways, which in turn regulate cellular phenotypes. Cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger that facilitates numerous signal transduction pathways; its production in cells is tightly balanced by ligand-stimulated receptors that activate adenylate cyclases (ACs), that is, "source" and by phosphodiesterases (PDEs) that hyd