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https://www.selleckchem.com/products/OSI-906.html Facile synthesis of 6- or 7-substituted coumarin-indomathacin hybrids (Coum-IDM) has been developed for specific cyclooxygenase-2 (COX-2) binding along with their intrinsic fluorescent properties. A mild and rapid condensation/dehydrative cyclization of 2-hydroxy benzaldehyde with activated indomethacin was carried out in one step under ultrasound irradiation. Coum-IDM4 was found to be the best of this series as it presented significant binding to COX-2 and exhibited higher fluorescent intensity in cancer cells than in normal cells. Therefore, in the light of drug development tools, this new hybrid system could be a potential targeted probe for COX-2-overexpressed inflammation and cancer-cell tracking. Systemic sclerosis (SSc) is characterized by widespread fibrosis and vascular complications. In this study, we utilized an assay for genome-wide chromatin accessibility to examine the chromatin landscape and transcription factor footprints in SSc. Dermal endothelial cells (ECs) and fibroblasts were isolated from healthy controls and patients with diffuse cutaneous (dc) SSc. ATAC-seq was performed to assess genome-wide chromatin accessibility at a read depth of approximately 150 million reads/sample. Transcription factor footprinting and motif binding analysis was performed followed by functional experiments. Chromatin accessibility was significantly reduced in dcSSc patients compared to healthy controls. Differentially accessible chromatin loci were enriched in pathways and gene ontologies involved in the nervous system, cell membrane projections and cilia motility, nuclear and steroid receptors, and nitric oxide. In addition, chromatin binding of transcription factors SNAI2, ETV2, and ELF1 was significpathways and transcription factors identified might present novel therapeutic approaches in SSc. In this study, we analyzed the whole exomes of CTSC gene in a family with history of PLS. Genomic DNA was extracted from pe

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